Version 3.0
Date revised: 4/26/2019

SAFETY DATA SHEETNational Diagnostics

Conforms to regulation (EC) no. EU 453/2010

SECTION 1 - IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product Identifier

Product Name: Acrylamide Product Number: EC-201

1.2 Relevant Identified Uses of the Substance/Mixture and Uses Advised Against

Investigational research by professional users

1.3 Details of the Supplier of the Safety Data Sheet

Manufacturer
National Diagnostics
305 Patton Drive
Atlanta, GA 30036
(404) 699-2121
(800) 526-3867
info@nationaldiagnostics.com

1.4 Emergency Telephone Number

ChemTel Inc.
Contract number MIS8894340
1-800 255-3924 (United States, Canada, Puerto Rico & US Virgin Islands)
01-800-099-0731 (Mexico)
400-120-0751 (China)
000-800-100-4086 (India)
1-300-954-583 (Australia)
0-800-591-6042 (Brazil)
+1-813-255-3924 (All other regions)

SECTION 2 - HAZARDS IDENTIFICATION

2.1 Classification of the Substance or Mixture

Classification according to Regulation (EC) No. 1272/2008 [EU-GHS/CLP]

H301 - Acute Toxicity-Oral (Category 3)
H312 - Acute Toxicity-Dermal (Category 4)
H315 - Skin Corrosion/Irritation (Category 2)
H317 - Skin Sensitizer (Category 1)
H319 - Serious Eye Damage/Eye Irritation (Category 2A)
H332 - Acute Toxicity-Inhalation (Category 4)
H340 - Germ Cell Mutagenicity (Category 1B)
H350 - Carcinogenicity (Category 1B)
H361 - Toxic to Reproduction (Category 2)
H372 - Specific Target Organ Toxicity Following Repeated Exposure (Category 1)

2.2 Label Elements

GHS LABEL ELEMENTS AND CLASSIFICATION
GHS Label Elements
ToxicHuman Health Hazard

DANGER

H301 - Toxic if swallowed
H312 - Harmful in contact with skin.
H315 - Causes skin irritation.
H317 - May cause an allergic skin reaction.
H319 - Causes serious eye irritation.
H332 - Harmful if inhaled.
H340 - May cause genetic defects.
H350 - May cause cancer.
H361 - Suspected of damaging fertility or the unborn child.
H372 - Causes damage to organs through prolonged or repeated exposure.
P201 - Obtain special instructions before use.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician .
P308+P360 - IF ON CLOTHING: Rinse immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P308+P313 - IF exposed or concerned: Call a POISON CENTER or doctor/physician.

  
  

2.3 Other Hazards

EMERGENCY OVERVIEW
CHRONIC TOXICITY HAZARD: Acrylamide is a neurotoxin which can be absorbed orally, dermally or by inhalation. Signs of exposure include tingling in the extremities and/or loss of coordination.

SECTION 3 - COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substance

Chemical Names/Description

2-Propenamide

Chemical Formula

C3H5NO

Component List

Component % Comp. CAS # EC #
Acrylamide>98.5% 79-06-1  201-173-7 


SECTION 4 - FIRST AID MEASURES

4.1 Description of First Aid Measures

Inhalation

Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.

Ingestion

Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Call a physician.

Skin

Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.

Eyes

Immediately flush eyes with plenty of water for at least fifteen minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

4.2 Most Important Symptoms and Effects, Both Acute and Delayed

Inhalation

Contact with this material by inhalation may cause nervous system effects. See ingestion effects for more details.

Ingestion

Contact with this material by any route (eyes/skin, inhalation or ingestion) may cause nervous system effects (neurotoxicity). These effects can result from a single overexposure but are more likely to occur after repeated exposures to small amounts over a period of several days or weeks. Signs and symptoms of toxic effects include increased sweating of the hands and feet, numbness, tingling and weakness in the extremeties, unsteady gait and decreased reflexes

Skin

Acrylamide is readily absorbed through unbroken skin. If the exposure route is dermal, the signs and symptoms described above under 'Signs and Symptoms of Overexposure - Ingestion' may be preceded by peeling and redness of skin at the areas of exposure, normally the hands and feet.

Eyes

Contact with this material by eyes may cause nervous system effects. See 'Signs and Symptoms of Overexposure - Ingestion' above for more details.

4.3 Indication of Any Immediate Medical Attention and Special Treatment Needed

Unknown/not applicable

SECTION 5 - FIRE FIGHTING MEASURES

5.1 Extinguishing media

Water spray, dry chemical, alcohol-resistant foam, or carbon dioxide.

5.2 Special Hazards Arising from the Substance/Mixture

Hazardous Combustion Products

Thermal decomposition products may include toxic oxides of nitrogen and carbon.

Hazardous Decomposition Products

Burning may produce ammonia, carbon monoxide, carbon dioxide, nitrogen oxides. Hydrogen gas.

Hazardous Polymerization

May occur

5.3 Advice for Firefighters

In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

5.4 Further Information

No data available.

SECTION 6 - ACCIDENTAL RELEASE MEASURES

6.1 Personal Precautions

Wear appropriate protective equipment as specified in Section 8.

6.2 Environmental Precautions

Prevent discharge into the environment. Dike spills and stop leakage where practical. Do not allow material to enter drains.

6.3 Methods and Materials for Containment and Cleaning Up

Remove all sources of ignition. Ventilate area. Wear appropriate personal protective equipment (Sec.8). Clean up spills in a manner that does not disperse dust into the air. Reduce airborne dust and prevent scattering by moistening with water.

6.4 References to Other Sections

For disposal information see Section 13. For protective clothing and equipment see Section 8.

SECTION 7 - HANDLING AND STORAGE

7.1 Precautions for Safe Handling

Avoid contact and inhalation. Do not get in eyes, on skin, on clothing. Wash thoroughly after handling. Wear special protective equipment (Sec. 8) where exposures may exceed established levels.

7.2 Conditions for Safe Storage (including any incompatibles)

Keep in a tightly closed container, stored in a cooled, dry, ventilated area. Protect from physical damage. Isolate from incompatible materials (section 10).

Incompatibles

Acrylamide reacts with acids, oxidizing agents, and bases. Spontaneously reacts with hydroxyl-, amino-, and sulfhydryl- containing compounds. Avoid vinyl polymerization initiators or contamination with aluminum, iron, copper, brass, and bronze.

7.3 Specific End Uses

Investigational research by professional users

SECTION 8 - EXPOSURE CONTROLS/PERSONAL PRECAUTIONS

8.1 Control Parameters

ACGIH Threshold Limit Value (TLV):

0.03 mg/m3

OSHA Permissible Exposure Limit (PEL):

0.3 mg/m3 (TWA) (skin) for solid

8.2 Exposure Controls

Engineering Controls

A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source.

Respiratory Protection

If exposure limits are exceeded, wear a full-face respirator with organic vapor cartridge and high efficiency dust mist filter. Beyond fifty times exposure limits or when exposure levels are not known, wear a full-face piece positive pressure respirator.

Eye Protection

Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.

Skin Protection

Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.


SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on Basic Physical & Chemical Properties

a. AppearanceWhite, crystalline solidb. OdorOdorless
c. Odor ThresholdNoned. pHNo information found
e. Melting/Freezing Point (oC)84.5f. Boiling point (oC)125
g. Flash Point (oC)not availableh. Evaporation RateNo information found
i. FlammabilityN.A.j. Upper/Lower Flammability or Explosive LimitsN.A.
k. Vapor Pressure0.007 mmHg @ 20 Cl. Vapor Density (Air = 1)2.45
m. Relative Density1.12 @ 30 Cn. Water Solubility216g/100g H20 @ 30 C
o. Partition Coefficient n-octanol/waterlog Kow=-0.67p. Autoignition Temperature (oC)394
q. Decomposition Temperature (oC)No datar. ViscosityNo data available.
s. Explosive PropertiesNo datat. Oxidizing PropertiesNot an oxidizer

SECTION 10 - STABILITY AND REACTIVITY

10.1 Reactivity

Reacts with vinyl polymerization initiators to produce polymer- this reaction is exothermic and may produce a hazardous condition.

10.2 Chemical Stability

May polymerize explosively. Thermally unstable. Polymerization can occur through exposure to heat, UV light, oxidizers or peroxides.

10.3 Possibility of Hazardous Reactions

May occur

10.4 Conditions to Avoid

Heat, shock, UV light, and incompatibles.

10.5 Incompatible Materials

Acrylamide reacts with acids, oxidizing agents, and bases. Spontaneously reacts with hydroxyl-, amino-, and sulfhydryl- containing compounds. Avoid vinyl polymerization initiators or contamination with aluminum, iron, copper, brass, and bronze.

10.6 Hazardous Decomposition Products

Burning may produce ammonia, carbon monoxide, carbon dioxide, nitrogen oxides. Hydrogen gas.

SECTION 11 - TOXICOLOGICAL INFORMATION

Product LD50 Values

Oral Rat LD50 (mg/kg)

294

Dermal Rabbit LD50 (mg/kg)

252

Component Cancer List Status

 NTP Carcinogen 
 KnownAnticipatedIARC Category
AcrylamideNoYes2A

Potential Health Effects

Inhalation

May cause drowsiness, tingling sensations, fatigue, weakness, stumbling, slurred speech, and shaking. May cause central and peripheral nervous system damage. Severe intoxications may cause permanent nerve damage. Causes irritation to the respiratory tract.

Ingestion

Toxic! May cause systemic poisoning. May cause drowsiness, tingling sensations, fatigue, weakness, stumbling, slurred speech, and shaking. May cause central and peripheral nervous system damage. Severe intoxication may cause permanent nerve damage. May affect reproductive system and act as a teratogen.

Skin

May cause irritation and redness. Can be absorbed through the skin causing systemic poisoning; symptoms may parallel ingestion.

Eyes

Acrylamide solutions may cause eye irritation.

Carcinogenicity

Acrylamide is suspected as a cancer hazard. May cause cancer. Listed by NTP as a suspected carcinogen. Acrylamide is known to the State of California to cause cancer.

Mutagenicity

Acrylamide was negative in the Ames assay both with and without metabolic activation.

Reproductive Toxicity

Acrylamide induced male reproductive toxicity has been demonstrated in Long-Evans rats where given greater than or equal to 15 mg/kg/day acrylamide orally by gavage for five consecutive days. In this study, males receiving greater than or equal to 15 mg/kg/day acrylamide had a reduced fertility index.

Teratogenic Effects

Not Available.

Routes of Entry

Contact with this material by any route of exposure (eye/skin, inhalation or ingestion) may cause serious adverse health consequences.

Target Organ Statement

Not Available.

SECTION 12 - ECOLOGICAL INFOMATION

12.1 Toxicity

 VertebratesInvertebratesAlgaeMicroorganisms
Aquatic Toxicity
(ppm unless otherwise noted)
96 hr LC50: 180ppm (Rainbow Trout)48-hour EC50: 98 mg/l (Daphnea)ICA50 (growth inhibition): 67.7 mg/l (Selenastrum capricornutum)No data

 BirdsArthropodsPlantsMicroorganisms
Terrestrial Environment Toxicity
(ppm unless otherwise noted)
No dataNo dataNo dataNo data

12.2 Persistence and Degradability

Readily biodegradable: The test material was found to degrade approximately 100% in 28 days in the OECD Closed Bottle Test (301D).

12.3 Bioaccumulative Potential

No data

12.4 Mobility in Soil

No data

12.5 Results of PBT and vPvB Assessment

Not PBT or vPvB

12.6 Other Adverse Effects

No data


SECTION 13 - DISPOSAL CONSIDERATIONS

13.1 Waste Treatment Methods

Offer surplus or non-recyclable product to licensed disposal company. Disposal is subject to user compliance with applicable law and product characteristics at time of disposal. Dispose of packaging as product.


SECTION 14 - TRANSPORT INFORMATION

  ADR/RID IATA IMO DOT
14.1 UN Number 2074207420742074
14.2 Shipping NameAcrylamide, solidAcrylamide, solidAcrylamide, solidAcrylamide, solid
14.3 Hazard Class6.16.16.16.1
14.4 Packing GroupIIIIIIIIIIII
14.5 Environmental HazardsN.A.N.A.Not regulatedN.A.
14.6 Special PrecautionsN.A.N.A.N.A.N.A.

SECTION 15 - REGULATORY INFORMATION

15.1 Safety, Health and Environmental Regulations/Legislation Specific for the Substance/Mixture

United States

TSCA Regulatory Statement

All intentional ingredients are listed on the TSCA Inventory.

SARA 311/312 Hazard Categories
ComponentFirePressureReactivityAcuteChronic
AcrylamideNoNoYesYesYes

Europe

EEC Regulatory

All intentional ingredients are listed on the European EINECS Inventory.

SECTION 16 - OTHER INFORMATION

Revisional Updates

4/26/2019 - Updated Section 1.4
5/29/2015 - Updated Sections 2.1 and 3.1
5/24/2013 - Released Version 1.0

NFPA Codes

Health 2   Flammability 1  Reactivity 1

MANUFACTURER DISCLAIMER: The information given herein is offered in good faith as accurate, but without guarantee. Conditions of the use and suitability of the product for particular uses are beyond our control. All risks of use of the product are therefore assumed by the user. Nothing is intended as a recommendation for uses which infringe valid patents or as extending license under valid patents. Appropriate warnings and safe handling procedures should be provided to handlers and users.