Version 3.0
Date revised: 4/26/2019

SAFETY DATA SHEETNational Diagnostics

Conforms to regulation (EC) no. EU 453/2010

SECTION 1 - IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product Identifier

Product Name: Tris Product Number: EC-406

1.2 Relevant Identified Uses of the Substance/Mixture and Uses Advised Against

Investigational research by professional users

1.3 Details of the Supplier of the Safety Data Sheet

Manufacturer
National Diagnostics
305 Patton Drive
Atlanta, GA 30036
(404) 699-2121
(800) 526-3867
info@nationaldiagnostics.com

1.4 Emergency Telephone Number

ChemTel Inc.
Contract number MIS8894340
1-800 255-3924 (United States, Canada, Puerto Rico & US Virgin Islands)
01-800-099-0731 (Mexico)
400-120-0751 (China)
000-800-100-4086 (India)
1-300-954-583 (Australia)
0-800-591-6042 (Brazil)
+1-813-255-3924 (All other regions)

SECTION 2 - HAZARDS IDENTIFICATION

2.1 Classification of the Substance or Mixture

Classification according to Regulation (EC) No. 1272/2008 [EU-GHS/CLP]

H315 - Skin Corrosion/Irritation (Category 2)
H319 - Serious Eye Damage/Eye Irritation (Category 2A)
H335 - Specific Target Organ Toxicity, Single Exposure (Category 3)

2.2 Label Elements

GHS LABEL ELEMENTS AND CLASSIFICATION
GHS Label Elements
Harmful 

WARNING

H315 - Causes skin irritation.
H319 - Causes serious eye irritation.
H335 - May cause respiratory irritation.
P261 - Avoid breathing dust/fume/gas/mist/vapors/spray.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P304+P341 - IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

  
  

2.3 Other Hazards

None found.

SECTION 3 - COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substance

Chemical Names/Description

TRIS; Tris (Hydroxymethyl) Aminomethane; 2-Amino-2-(hydroxymethyl)-1,3-propanediol

Chemical Formula

C4H11NO3

Component List

Component % Comp. CAS # EC #
Tris-Base100 77-86-1  201-064-4 


SECTION 4 - FIRST AID MEASURES

4.1 Description of First Aid Measures

Inhalation

Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.

Ingestion

Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Call a physician.

Skin

Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.

Eyes

Immediately flush eyes with plenty of water for at least fifteen minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

4.2 Most Important Symptoms and Effects, Both Acute and Delayed

Inhalation

Coughing, shortness of breath.

Ingestion

Symptoms may include nausea, vomiting, and diarrhea. Large oral doses may cause weakness, collapse, blood clotting, and coma. The estimated lethal dose of Tris Base is 50 grams dry solid.

Skin

Redness, itching, and pain.

Eyes

Redness, itching, and pain.

4.3 Indication of Any Immediate Medical Attention and Special Treatment Needed

Unknown/not applicable

SECTION 5 - FIRE FIGHTING MEASURES

5.1 Extinguishing media

Water spray, dry chemical, alcohol-resistant foam, or carbon dioxide.

5.2 Special Hazards Arising from the Substance/Mixture

Hazardous Combustion Products

Thermal decomposition products may include toxic oxides of nitrogen and carbon.

Hazardous Decomposition Products

Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.

Hazardous Polymerization

Will not occur under normal conditions of use (See Sections 10.4 & 10.5).

5.3 Advice for Firefighters

In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

5.4 Further Information

No data available.

SECTION 6 - ACCIDENTAL RELEASE MEASURES

6.1 Personal Precautions

Wear appropriate protective equipment as specified in Section 8.

6.2 Environmental Precautions

Prevent discharge into the environment. Dike spills and stop leakage where practical. Do not allow material to enter drains.

6.3 Methods and Materials for Containment and Cleaning Up

Remove all sources of ignition. Ventilate area of leak or spill. Pick up and place in a suitable container for reclamation or disposall, using a method that does not generate dust.

6.4 References to Other Sections

For disposal information see Section 13. For protective clothing and equipment see Section 8.

SECTION 7 - HANDLING AND STORAGE

7.1 Precautions for Safe Handling

Avoid contact and inhalation. Do not get in eyes, on skin, on clothing. Wash thoroughly after handling.

7.2 Conditions for Safe Storage (including any incompatibles)

Keep in a tightly closed container, stored in a cooled, dry, ventilated area away from sources of heat or ignition. Protect from physical damage. Isolate from incompatible materials (section 10).

Incompatibles

No incompatibility data found.

7.3 Specific End Uses

Investigational research by professional users

SECTION 8 - EXPOSURE CONTROLS/PERSONAL PRECAUTIONS

8.1 Control Parameters

ACGIH Threshold Limit Value (TLV):

none established

OSHA Permissible Exposure Limit (PEL):

none established

8.2 Exposure Controls

Engineering Controls

A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source.

Respiratory Protection

For conditions of use where exposure to the substance is apparent, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator.

Eye Protection

Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.

Skin Protection

Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.


SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on Basic Physical & Chemical Properties

a. AppearanceTransparent, colorless crystals.b. OdorNone
c. Odor ThresholdN.A.d. pH10.4 (0.1 M soln.)
e. Melting/Freezing Point (oC)171-172f. Boiling point (oC)219-220
g. Flash Point (oC)N.A.h. Evaporation RateNo information found
i. FlammabilityN.A.j. Upper/Lower Flammability or Explosive LimitsN.A.
k. Vapor PressureNo information foundl. Vapor Density (Air = 1)No information found
m. Relative DensityNo information foundn. Water Solubility550 mg/mL
o. Partition Coefficient n-octanol/waterlog Pow = -2.31 p. Autoignition Temperature (oC)N.A.
q. Decomposition Temperature (oC)N.A.r. ViscosityNo data available.
s. Explosive PropertiesN.A.t. Oxidizing PropertiesNot an oxidizer

SECTION 10 - STABILITY AND REACTIVITY

10.1 Reactivity

Strong base- will react violently with acids or oxidizers. Corrosive to metals.

10.2 Chemical Stability

Stable under ordinary conditions of use and storage.

10.3 Possibility of Hazardous Reactions

Will not occur under normal conditions of use (See Sections 10.4 & 10.5).

10.4 Conditions to Avoid

Heat, incompatibles.

10.5 Incompatible Materials

No incompatibility data found.

10.6 Hazardous Decomposition Products

Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.

SECTION 11 - TOXICOLOGICAL INFORMATION

Product LD50 Values

Oral Rat LD50 (mg/kg)

5900

Dermal Rabbit LD50 (mg/kg)

no information found

Component Cancer List Status

 NTP Carcinogen 
 KnownAnticipatedIARC Category
Tris-BaseNoNoNone

Potential Health Effects

Inhalation

Causes irritation to the respiratory tract.

Ingestion

Causes irritation and reddening to the mucous membranes of the mouth, esophagus, and gastrointestinal tract.

Skin

Causes irritation to the skin.

Eyes

Causes irritation to the eyes.

Carcinogenicity

Not listed as a carcinogen by NTP or IARC.

Mutagenicity

No information found.

Reproductive Toxicity

No information found.

Teratogenic Effects

No information found.

Routes of Entry

Ingestion.

Target Organ Statement

No information available.

SECTION 12 - ECOLOGICAL INFOMATION

12.1 Toxicity

 VertebratesInvertebratesAlgaeMicroorganisms
Aquatic Toxicity
(ppm unless otherwise noted)
LC50 460mg/l (Golden ide)EC50: 59.8 mg/L (Daphnia)EC50: 473mg/l @ 48 hrsCE50>1000mg/L (3hrs)

 BirdsArthropodsPlantsMicroorganisms
Terrestrial Environment Toxicity
(ppm unless otherwise noted)
No dataNo dataNo dataNo data

12.2 Persistence and Degradability

Readily Biodegradable (>97% degradation at 28 days)

12.3 Bioaccumulative Potential

No data

12.4 Mobility in Soil

Log Koc 1.57-1.85

12.5 Results of PBT and vPvB Assessment

Not a PBT or vPvB

12.6 Other Adverse Effects

None


SECTION 13 - DISPOSAL CONSIDERATIONS

13.1 Waste Treatment Methods

Offer surplus or non-recyclable product to licensed disposal company. Disposal is subject to user compliance with applicable law and product characteristics at time of disposal. Dispose of packaging as product.


SECTION 14 - TRANSPORT INFORMATION

  ADR/RID IATA IMO DOT
14.1 UN Number N.A.N.A.N.A.N.A.
14.2 Shipping NameNot regulatedNot regulatedNot regulatedNot regulated
14.3 Hazard ClassN.A.N.A.N.A.N.A.
14.4 Packing GroupN.A.N.A.N.A.N.A.
14.5 Environmental HazardsN.A.N.A.Not regulatedN.A.
14.6 Special PrecautionsN.A.N.A.N.A.N.A.

SECTION 15 - REGULATORY INFORMATION

15.1 Safety, Health and Environmental Regulations/Legislation Specific for the Substance/Mixture

United States

TSCA Regulatory Statement

All intentional ingredients are listed on the TSCA Inventory.

SARA 311/312 Hazard Categories
ComponentFirePressureReactivityAcuteChronic
Tris-BaseNoNoNoYesNo

Europe

EEC Regulatory

All intentional ingredients are listed on the European EINECS Inventory.

SECTION 16 - OTHER INFORMATION

Revisional Updates

4/26/2019 - Updated Section 1.4
5/29/2015 - Updated Sections 2.1 and 3.1
8/7/2013- Released Version 1.0

NFPA Codes

Health 1   Flammability 1  Reactivity 0

MANUFACTURER DISCLAIMER: The information given herein is offered in good faith as accurate, but without guarantee. Conditions of the use and suitability of the product for particular uses are beyond our control. All risks of use of the product are therefore assumed by the user. Nothing is intended as a recommendation for uses which infringe valid patents or as extending license under valid patents. Appropriate warnings and safe handling procedures should be provided to handlers and users.