Version 3.0
Date revised: 4/26/2019
SAFETY DATA SHEET
Conforms to regulation (EC) no. EU 453/2010
SECTION 1 - IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1 Product Identifier
1.2 Relevant Identified Uses of the Substance/Mixture and Uses Advised Against
Investigational research by professional users
1.3 Details of the Supplier of the Safety Data Sheet
| Manufacturer National Diagnostics 305 Patton Drive Atlanta, GA 30036 (404) 699-2121 (800) 526-3867 info@nationaldiagnostics.com |
1.4 Emergency Telephone Number
ChemTel Inc.
Contract number MIS8894340
1-800 255-3924 (United States, Canada, Puerto Rico & US Virgin Islands)
01-800-099-0731 (Mexico)
400-120-0751 (China)
000-800-100-4086 (India)
1-300-954-583 (Australia)
0-800-591-6042 (Brazil)
+1-813-255-3924 (All other regions)
SECTION 2 - HAZARDS IDENTIFICATION
2.1 Classification of the Substance or Mixture
Not a hazardous substance or mixture according to regulation (EC) No. 1272/2008.
2.2 Label Elements
This product has no labeling elements associated with EC directives or respective national laws.
2.3 Other Hazards
None found.
SECTION 3 - COMPOSITION/INFORMATION ON INGREDIENTS
3.2 Mixture
Chemical Names/Description
Tris hydrochloride solution
Component List
| Component | % Comp. | CAS # | EC # | 1278/2008 Classification |
|---|---|---|---|---|
| Tris Hydrochloride | 10 - 20 | 1185-53-1 | 214-684-5 | H315, H319, H335 |
SECTION 4 - FIRST AID MEASURES
4.1 Description of First Aid Measures
Inhalation
If breathing, move person to fresh air. If not breathing give artificial respiration. Consult a physician.
Ingestion
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Skin
Wash off with soap and plenty of water. Consult a physician.
Eyes
Flush eyes with water as a precaution.
4.2 Most Important Symptoms and Effects, Both Acute and Delayed
Inhalation
Symptoms may include coughing and shortness of breath.
Ingestion
Symptoms may include irritation and reddening to the mucous membranes of the mouth, esophagus, and gastrointestinal tract.
Skin
Symptoms may include irritation with redness and pain.
Eyes
Symptoms may include irritation, redness, pain, and corneal damage.
4.3 Indication of Any Immediate Medical Attention and Special Treatment Needed
Unknown/not applicable
SECTION 5 - FIRE FIGHTING MEASURES
5.1 Extinguishing media
Water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special Hazards Arising from the Substance/Mixture
Hazardous Combustion Products
N.A.
Hazardous Decomposition Products
No data available.
Hazardous Polymerization
No data found.
5.3 Advice for Firefighters
Gloves, approved eyewear and respiratory controls if needed.
5.4 Further Information
No data available.
SECTION 6 - ACCIDENTAL RELEASE MEASURES
6.1 Personal Precautions
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventillation.
6.2 Environmental Precautions
Prevent discharge into the environment. Dike spills and stop leakage where practical. Do not allow material to enter drains.
6.3 Methods and Materials for Containment and Cleaning Up
Contain and clean up spill immediately, prevent from entering floor drains. Contain liquids using absorbents. Shovel all spill materials into disposal drum. Scrub spill area with detergent, flush with copious amounts of water.
6.4 References to Other Sections
For disposal information see Section 13. For protective clothing and equipment see Section 8.
SECTION 7 - HANDLING AND STORAGE
7.1 Precautions for Safe Handling
No information available.
7.2 Conditions for Safe Storage (including any incompatibles)
Store tightly capped in a dark area.
Incompatibles
Bases, oxidizing agents, acids, aldehydes, copper, brass, and aluminum.
7.3 Specific End Uses
Investigational research by professional users
SECTION 8 - EXPOSURE CONTROLS/PERSONAL PRECAUTIONS
8.1 Control Parameters
ACGIH Threshold Limit Value (TLV):
None established
OSHA Permissible Exposure Limit (PEL):
None established
8.2 Exposure Controls
Engineering Controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Respiratory Protection
When appropriate, use a full-face respirator with multiple purpose combination or type ABEK respirator cartridges as a backup to engineering controls. If respirator is sole means of protection use a full-face supplied air respirator.
Eye Protection
Safety glasses with side shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH or EN166.
Skin Protection
Handle with gloves. Inspect gloves prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on Basic Physical & Chemical Properties
| a. Appearance | Clear, colorless solution | b. Odor | None |
| c. Odor Threshold | N.A. | d. pH | 7.6 |
| e. Melting/Freezing Point (oC) | 0 | f. Boiling point (oC) | 101 |
| g. Flash Point (oC) | N.A. | h. Evaporation Rate | Water |
| i. Flammability | N.A. | j. Upper/Lower Flammability or Explosive Limits | N.A. |
| k. Vapor Pressure | 17 | l. Vapor Density (Air = 1) | 0.62 |
| m. Relative Density | 1.01 | n. Water Solubility | Miscible |
| o. Partition Coefficient n-octanol/water | p. Autoignition Temperature (oC) | N.A. | |
| q. Decomposition Temperature (oC) | Not applicable. | r. Viscosity | N.A. |
| s. Explosive Properties | N.A. | t. Oxidizing Properties | N.A. |
SECTION 10 - STABILITY AND REACTIVITY
10.1 Reactivity
N.A.
10.2 Chemical Stability
Stable
10.3 Possibility of Hazardous Reactions
No data found.
10.4 Conditions to Avoid
No data available.
10.5 Incompatible Materials
Bases, oxidizing agents, acids, aldehydes, copper, brass, and aluminum.
10.6 Hazardous Decomposition Products
No data available.
SECTION 11 - TOXICOLOGICAL INFORMATION
Product LD50 Values
Oral Rat LD50 (mg/kg)
N.A.
Dermal Rabbit LD50 (mg/kg)
N.A.
Component Cancer List Status
| NTP Carcinogen | |||
| Known | Anticipated | IARC Category | |
|---|---|---|---|
| Tris Hydrochloride | No | No | None |
Potential Health Effects
Inhalation
May cause respiratory tract irritation. The toxigological properties of this substance have not been fully investigated.
Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. The toxicological properties of this substance have not been fully investigated.
Skin
Causes skin irritation. Causes redness and pain.
Eyes
Causes eye irritation. Causes redness and pain.
Carcinogenicity
Not listed by OSHA, ACGIH, NIOSH, NTP or IARC as a known or anticipated carcinogen.
Mutagenicity
No information available.
Reproductive Toxicity
No information available.
Teratogenic Effects
No information available.
Routes of Entry
Inhalation, ingestion or skin contact.
Target Organ Statement
No information available
SECTION 12 - ECOLOGICAL INFOMATION
12.1 Toxicity
| Vertebrates | Invertebrates | Algae | Microorganisms | |
|---|---|---|---|---|
Aquatic Toxicity (ppm unless otherwise noted) | No data | No data | No data | No data |
| Birds | Arthropods | Plants | Microorganisms | |
|---|---|---|---|---|
Terrestrial Environment Toxicity (ppm unless otherwise noted) | No data | No data | No data | No data |
12.2 Persistence and Degradability
No data
12.3 Bioaccumulative Potential
No data
12.4 Mobility in Soil
No data
12.5 Results of PBT and vPvB Assessment
No data
12.6 Other Adverse Effects
None
SECTION 13 - DISPOSAL CONSIDERATIONS
13.1 Waste Treatment Methods
Offer surplus or non-recyclable product to licensed disposal company. Disposal is subject to user compliance with applicable law and product characteristics at time of disposal. Dispose of packaging as product.
SECTION 14 - TRANSPORT INFORMATION
| ADR/RID | IATA | IMO | DOT | |
|---|---|---|---|---|
| 14.1 UN Number | N.A. | N.A. | N.A. | N.A. |
| 14.2 Shipping Name | N.A. | N.A. | N.A. | N.A. |
| 14.3 Hazard Class | N.A. | N.A. | N.A. | N.A. |
| 14.4 Packing Group | N.A. | N.A. | N.A. | N.A. |
| 14.5 Environmental Hazards | N.A. | N.A. | Not regulated | N.A. |
| 14.6 Special Precautions | N.A. | N.A. | N.A. | N.A. |
SECTION 15 - REGULATORY INFORMATION
15.1 Safety, Health and Environmental Regulations/Legislation Specific for the Substance/Mixture
United States
TSCA Regulatory Statement
All intentional ingredients are listed on the TSCA Inventory.
SARA 311/312 Hazard Categories
| Component | Fire | Pressure | Reactivity | Acute | Chronic |
|---|---|---|---|---|---|
| Tris Hydrochloride | No | No | No | Yes | No |
Europe
EEC Regulatory
All intentional ingredients are listed on the European EINECS Inventory.
SECTION 16 - OTHER INFORMATION
Revisional Updates
4/26/2019 - Updated Section 1.4
5/29/2015 - Updated Sections 2.1 and 3.2
4/16/2013 - Released Version 1.0
NFPA Codes
Health 0 Flammability 0 Reactivity 0
Dangers
Tris Hydrochloride
H315 - Causes skin irritation.
H319 - Causes serious eye irritation.
H335 - May cause respiratory irritation.
MANUFACTURER DISCLAIMER: The information given herein is offered in good faith as accurate, but without guarantee. Conditions of the use and suitability of the product for particular uses are beyond our control. All risks of use of the product are therefore assumed by the user. Nothing is intended as a recommendation for uses which infringe valid patents or as extending license under valid patents. Appropriate warnings and safe handling procedures should be provided to handlers and users.